INTRODUCTION

Metabolic and endocrine alterations during childhood are Special Health Care Needs (SCHN), and they require health interventions by multidisciplinary teams to guarantee the best level of well-being possible, which includes optimal preventive and therapeutic goals in oral health (1).

Congenital hypothyroidism (CH) is the most common endocrine disease in pediatric population (2), originated by an inappropriate development of thyroid gland in the most of the cases (3), with a diminished availability of thyroid hormones in tissues and impacting in body metabolism (4). Early detection of CH is accomplished through newborn screening tests, and it has been identified a global prevalence of approximately 1:4,000 newborns with CH. This tests allow to establish a timely hormone replacement therapy (HRT) (2,3,5).

CH has influence in four principal aspects of oral health care in the pediatric patients:

Growth and development. Thyroid hormones act as regulators of bone metabolism and skeletal maturity through endochondral ossification (6). In children with CH, growth pattern could be delayed and be manifested as short stature, brachycephaly and open cranial sutures (4,7,8).

Patient cooperation.An optimal brain development depends on thyroid hormones during the first three years of life, and CH is the most common preventable cause of mental retardation (3). So, it is important to make adjustments in behavior guidance (4) and to establish communication strategies with children that are compatible with their cognitive skills (8).

Oral conditions. Children with CH may present dental anomalies caused by a reduction of calcium and phosphorus in enamel, this anomalies could range from diffuse opacities to severe enamel hypoplasia. Also, gingival swelling may compromise periodontal health (2,9,10). Malocclusion could occur due to delayed exfoliation of primary teeth and delayed eruption of permanent ones (11,12).

General health status. A lack of an adequate HRT in children with CH could trigger cardiovascular, respiratory, gastrointestinal and neuromuscular affections (4). So, adherence to medical treatment should be assured in order to avoid complications during dental appointment (2).

The aim of this paper is to report the dental treatment of a child with hypothyroidism and the follow up with recommendations for its dental management in pediatric dentistry.

CASE REPORT

A four year-five months old male attended dental service for the first time at the Postgraduate Pediatric Dentistry Clinic of San Luis Potosi University, San Luis Potosi, Mexico complaining of dental caries accompanied by his mother, who answered the questionnaire of the medical records and signed a written inform consent. The patient was diagnosed with CH at one year and three months of age because of delayed growth, and he didn’t receive the newborn screening tests as he was hospitalized because of thrombocytopenia. Current HRT was Levothyroxine 50 micrograms daily (3). He was considered to be in euthyroid state with favorable evolution, because his thyroid stimulating hormone (TSH) levels and free thyroxine (T4) index were in adequate ranges according to his age. His corporal weight was 15 kg and his height was 1.00 m. His primary vital signs were: body temperature 36.8°C, blood pressure 105/60 mmHg, heart rate 92 beats per minute and respiratory rate 20 breaths per minute.

The patients’ mother referred that he presented speech and learning impairment, and he was attending language therapy service at that moment. In regard of the nutritional and hygiene habits, he consumed high-carbohydrate diet and he only achieved oral hygiene once a day assisted by his mother. The patient presented oral habits such as frequent lip suction and nocturnal mouth breathing. The extraoral examination revealed a brachycephalic skull with straight profile, and also facial characteristics of hypothyroidism: hypertelorism, periorbital puffiness, wide neck and depressed nasal bridge (Figure 1). The intraoral examination revealed thick lips, gum pigmentation, bilateral mesial step and anterior crossbite. There were observed deep cavities in all primary second molars and primary mandibular right molar. Maxillary central incisors presented enamel hypoplasia (Figure 2).

Due to the extent of the treatment required and patients lack of cooperation, it was explained to the mother the possible use of advanced behavior guidance techniques, such as protective stabilization, sedation or general anesthesia (1). In the first dental appointment it was carried out a dental prophylaxis using basic communication techniques, and the proper brushing technique was explained to the mother, with fluoride toothpaste twice a day (1). Every appointment the child was encouraged to visit the Pediatric Dental Clinic Playroom prior to dental treatment, so he could interact with specialists trained in Pedagogy and learn about dental procedures through games and activities, as he developed confidence and diminished the anxiety (Figure 3) (13).

The dental treatment consisted in pit and fissure sealants in primary maxillary right and primary mandibular left molars, resin- based composite in primary maxillary left molar, pulpotomies in primary maxillary second molars, pulpectomies in primary mandibular second molars, stainless steel crowns in primary maxillary central incisors, primary mandibular right molar and in all primary second molars (Figure 4). In each appointment local anesthesia was achieved with one cartridge of 2% lidocaine with 1:100,000 epinephrine. Once the dental treatment was finished, it began a follow-up every six weeks for the next 15 months, where there was realized dental prophylaxis, brushing techniques reinforcement and fluoride varnish application.

During the last appointments, there were assessedthedentalexfoliationofprimarymandibular incisors and dental eruption of permanent incisors and permanent first molars by clinical observation and radiographic images. There have been detected enamel opacities in newly erupted permanent teeth (probably hypomineralization), which are in current observation (Figure 5). Overall, dental treatment was achieved successfully using basic communication and guidance behavior techniques.

Figure 1
Extraoral examination. (A) Profile view. (B) Frontal view.

Figure 2
Pre-treatment intraoral examination. (A) Maxillary occlusal view. (B) Frontal view. (C) Overbite. (D) Mandibular occlusal view. (E) Right occlusion. (F) Left occlusion.

Figure 3
Patient in Pediatric Dental Clinic Playroom.

Figure 4
Post-treatment intraoral examination. (A) Maxillary occlusal view. (B) Frontal view. (C) Overbite. (D) Mandibular occlusal view. (E) Right occlusion. (F) Left occlusion.

Figure 5
Follow-up of newly erupted permanent teeth with diffuse opacities of enamel. (A) Permanent mandibular right first molar. (B) Permanent mandibular central incisors. (C) Permanent mandibular left first molar. (D) Orthopantomography.

DISCUSSION

Pediatric Dentistry plays an important role in early detection and diagnosis of thyroid anomalies, so it must be recommended the realization of screening tests for all newborns (10), so appropriate treatment could begin in a timely manner to avoid physical and cognitive development issues and to minimize oral and systemic diseases (1).

The patient was identified to have a metabolic anomaly as he entered to the dental clinic, because of his characteristic physical features (short stature, brachycephalic skull, facial edema) (8), and the medical record answered by his mother confirmed the presence of CH. It is mandatory to be informed about the medical status of patients with endocrine alterations, and basal values must be known in order to recognize a status of hypotension, hypothermia or bradycardia (4). Also, pediatric dentists should encourage patients’ follow-up with an endocrinologist.

It must be paid attention to behavior guidance in patients with learning disorders to win their cooperation and to reduce stress, so advanced behavior guidance techniques could be avoided, as pharmacological sedation with midazolam and other Central Nervous System depressants may aggravate lethargy or compromise heart and respiratory rates in patients with CH (12). In this particular case, there was noticed a favorable development in social, language and cooperative skills because of the time the patient spent at the Clinics Playroom (13) with the guidance of the Pedagogy specialists, and sedation or another advanced technique weren’t needed. Also, we instructed the patients’ mother to include healthy food in his diet, perform tooth brushing at home after every meal, encourage the child to be more participative and cooperative at the dental clinic, and maintain strict adherence to dental appointments. These recommendations may apply to parents of kids with similar conditions.

Considering that delayed dental eruption is associated with CH, it was prioritary to perform pulp therapies in primary teeth and to restore the masticatory function (2) along with preventive measures. It was decided to restore primary maxillary central incisors with stainless steel crowns due to enamel hypoplasia. At first it was considered to place reversed crowns to correct the anterior crossbite (14), nevertheless, the excessive overjet didn’t allow it. For operatory procedures, local anesthesia was achieved with one cartridge of lidocaine with epinephrine, previously corroborated that the patient didn’t have any heart disease and limiting anesthetic dose according to patients weight (4).

It was unusually found that primary mandibular central incisors had early exfoliated and permanent central incisors and first molars were already erupting. Those teeth have presented enamel diffuse opacities, possibly associated with molar-incisor hypomineralization (9), so the patient underwent frequent follow-ups and fluoride varnish applications. The future monitoring plan is to assess craniofacial growth and development, management of the developing occlusion and continue with the preventive strategies. It is evident that the patient will require orthodontic intervention (4), which will be started when the patient was considered to be emotionally prepared to cooperate with oral appliances. At age seven, we expect the first permanent molars and permanent incisors to be fully or partially erupted, so we could start maxillary orthopedics to intercept class III malocclusion.

CONCLUSION

The medical and dental team should offer the best health care to patients with CH, emphasizing the importance of timely medical and dental treatments. On our side, pediatric dentists must teach effective oral hygiene tecnhiques (15), and also ensure patients compliance to dental treatment to achieve a caries-free status and avoiding the development of periodontitis in adulthood. Goals must be directed to win a positive cooperation during the appointments to guarantee patients physical and emotional wellbeing (1).

ACKNOWLEDGEMENTS

We'd like to thank the Pedagogy team at the Pediatric Dental Clinic Playroom for their valuable help in achieving patients' compliance every appointment: Castro-Hernández María del Carmen, Ramírez-Lara Paola Jassive, Esquivel-Hernández Rocío and Briones-González María Jovita.

REFERENCES

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