All cirrhotic patients and detectable DNA HBV must take antiviral treatment. Treatment should start with lamivudine or adenofir dipivoxil. Alpha interferon in any presentation is contraindicated. Constant monitoring (every 3 moths) of DNA HBV levels of patients with lamiduvine must be carried aout to detect drug resistance. When DNA HBV reappers or increases itself in 1 log<span name="style_sub">10, </span>it is believed that resistance against lamiduvine is being developed. In case of resistance, treatment with adenofir dipivoxil should be srted (every 3 months) of their renal function.it is believed that resistance against lamiduvine is being developed. In case of resistance, treatment with adenofir dipivoxil should be srted (every 3 months) of their renal function.

cirrhosis; treatment; lamivudina; adefovir