<span name="style_bold">Objective:</span> To describe the use of chemical insecticides throughout history as the main tool to fight against <span name="style_italic">Aedes aegypti</span>, a vector of dengue virus. <span name="style_bold">Methods: </span>A text mining approach was conducted on databases, such as PUBMED and SCIENCE DIRECT, using the keywords “<span name="style_italic">Aedes aegypti</span>”, combined with the words “insecticides”, “resistance”, “organochlorines”, “organophosphates”, “carbamates” and “pyrethroids”. Results related to historical information dealing with the chemical control of <span name="style_italic">Aedes aegypti</span>, in particular those containing data on insecticide resistance for this species, were scrutinized and analyzed. <span name="style_bold">Results: </span>Different chemical groups have been utilized to control <span name="style_italic">A. aegypti</span>, including organochlorine, organophosphate, carbamate and pyrethroid insecticides. In general, the tendency has been to replace a particular pesticide, for which resistance had been detected, for a new one, mosquito-sensitive, and with little evidence of deleterious effects derived from its use. The spread of resistance has been registered in several countries of America, Asia and Africa. Two mechanisms have been highly cited to be responsible for the resistance; the increase activity of detoxifying enzymes, and structural changes in the insecticide target site, mostly within the central nervous system. <span name="style_bold">Conclusion: </span>Excessive use of chemical insecticides and the lack of dosing control have led to widespread resistance in <span name="style_italic">A. aegypti</span>, as no “safer” alternative chemical options are available for vector control in different countries, impacting human health., as no “safer” alternative chemical options are available for vector control in different countries, impacting human health.

Aedes; Vector control; Insecticide Resistance; Toxic Substances