The limited capacity of essential biosynthetic precursors mycoplasma enabled them to develop molecular mechanisms for acquisition from their hosts. <span name="style_bold">Objective: </span>To determine the ability of DNA degradation in mycoplasma isolated from clinical samples. <span name="style_bold">Methods: </span>From clinical samples of throat and vaginal swabs mycoplasmas were isolated by microbiological method and validated by PCR. The positive samples were evaluated for their ability to degrade DNA halo formation method on agar. <span name="style_bold">Results: </span>the ability to degrade DNA from clinical isolates of mycoplasma was evident and showed a significant difference (P &lt;0.05) compared to the reference strain. <span name="style_bold">Conclusions: </span>Mycoplasma in clinical isolates have DNase activity, implying a role for the acquisition of nucleic acid precursors, and conditioning the host cells´ alteration.Mycoplasma in clinical isolates have DNase activity, implying a role for the acquisition of nucleic acid precursors, and conditioning the host cells´ alteration.

Mycoplasmas; Pharynx; Vaginal Smears; DNA Fragmentation