The first cause of morbidity-mortality all over the world is represented by the cardiovascular diseases. The acute infarct of myocardium is the most dramatic expression within the acute coronary syndrome and the coronary plaque rupture, the most frequently physiopathology mechanism involved. In the last few years the objective of the treatment has changed, from obtaining permeability in the epicardial arteries to reaching a suitable level of perfusion in the microvascular circuit. The optimization of the therapeutic strategy obtains through a precocious and effective reperfusion (fibrinolytic and/or angioplasty) and the suitable helping drug selection (aspirin, clopidogrel and anticoagulants) that has demonstrated clinical benefits in clinical trials

Acute myocardial infartion; reperfusion; fibrinolitics; angioplasty