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Artículo • Rev. biol. trop 66 (4) • Dec 2018 • https://doi.org/10.15517/rbt.v66i4.32121 linkcopy

Open-access Inhibition of β-hematin formation of Colombian species of Piper spp. and Calophyllum spp. as potential antimalarial agents

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    Abstract

    New antimalarial agents from plants are studied as alternatives in the treatment of malaria. The main antimalarials such as chloroquine have several mechanisms of action against parasites, one of which is the inhibition of polymerization of the heme group, a model that has allowed the design of new antimalarial candidates. In this sense the objective of this work was to evaluate extracts of genus Piper and Calophyllum plants on the inhibition capacity of β-hematin. Inhibitory concentrations of β-hematin are reported from 40 extracts of different polarity obtained from the species P. piedecuestanum, C. brasiliense, C. longinforium, and Calophyllum. sp. 19 extracts showed a greater potential to inhibit β-hematin with IC50 < 3 mg/ml. These activities mainly support future studies with the genus Calophyllum in the development and discovery of new antiplasmodial substances with known modes of action.

    Key words: antiplasmodial; chloroquine; extracts; polymerization; heme group

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    Universidad de Costa Rica Universidad de Costa Rica. Escuela de Biología, 2060 San José, Costa Rica, San Pedro, San José, CR, 2060, 2511-5500 , 2511-5550 - E-mail: rbt@biologia.ucr.ac.cr
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