Abstract

Human beings suffer elevated pregnancy failure rates after conception, reaching 10 to 15% of all clinically recognized pregnancies. The high psychological burden and frustration is common among couples who experience a miscarriage and moreover in those who present with recurrent pregnancy loss. This entity doesn’t have a clear definition, and it is described as the loss of 2 or 3 consecutive pregnancies before 20 weeks of gestation according to the American and European currents, respectively. It presents in 1 to 5% of couples who try to conceive depending on the definition used. Recurrent pregnancy loss majorly results from genetic causes which are greatly influenced by advanced maternal age. However, this is a multifactorial disorder in which not only genetic factors may play a role but anatomic, thrombophilia, endocrinologic, immunologic, infectious, and life style factors as well. Even after an exhaustive evaluation the underlying cause remains undetermined in up to 50% of cases.

Key Words: Miscarriage; recurrent pregnancy loss; live births rate; pregnancy; reproduction