In spite of the universal use of the vaccine, hepatitis B still is a public health problem in different areas around the world. Eventhough an effective suppression of viral replication by means of treatment with drugs is obtained; there is a potential reactivation when suspending the treatment. The therapeutic approach for non-respondents or relapses post treatment could be carried out with combinations of medicines or use of another type of drug with greater power.

hepatitis B; treatment; nonrespondent; relapses