Open-access <b>Description of testicular germ cell tumors, according to biopsies from the department of pathology, Mexico Hospital, Costa Rica from january 2003 to march 2011</b>

Abstracts

Background: 95% of testicular tumors are germ cell tumors (TGCT). These neoplasms have increased in number and have become more common in young people. The TGCTs are divided into two groups: seminomatous and non-seminomatous. The objective is to describe the TGCT based on pathological biopsy results at the Mexico hospital from 1<sup>st </sup>january 2003 to 31<sup>st </sup>march 2011. Methods: A descriptive study of the department of Pathology database, from which the cases of TGCTs were selected. Within the analysis, absolute and relative frequencies, confidence intervals, measures of dispersion and central tendency were calculated. Chi-square p &lt;0.05 was used for the trend. Results: 148 patients with germ cell tumors were selected. There was an increasing tendency in tumors with p &lt;0.003. Out of the total number of cases, 60.2% (89), CI 95% (52.2-68.1), occurred in males younger than thirty years old. Non-seminomatous TGCTs occurred in 59.5% (88) of the cases, CI 95% (51.5-67.3). The average age of those with non-seminoma was 26.4 years; DE 8.1, and of those with seminoma was 31 years; DE 7.5, with a difference of p &lt;0.001. Conclusions: There is a significant tendency towards the increase of TGCT, which is more frequent in patients under 30. The non-seminomatous TGCTs are the most frequent. The average age for non-seminomatous TGCTs is significantly lower than for the seminomatous. Limitations: incidences and prevalences were not calculated. Recommendations: to focus detection campaigns on the population at risk, and extend the study to other hospitals.

Germ cells; seminoma; biopsy; Costa Rica; testicular tumors


Justificación y objetivo: el 95% de los tumores testiculares son de células germinales. La presencia de estas neoplasias ha venido en aumento, y se han hecho más frecuentes en gente jóven. Los tumores testiculares de células germinales se dividen en dos grupos: seminomatosos y no seminomatosos. El objetivo fue caracterizar los con base en los resultados de biopsia del Patología del Hospital México, del 1º de enero del 2003, al 31 de marzo del 2011. Métodos: estudio descriptivo de una base de datos del servicio de Patología, en donde se seleccionaron los tumores testiculares de células germinales. En el análisis, se calcularon frecuencias absolutas, relativas, intervalos de confianza, medidas de dispersión y de tendencia central y Chi cuadrado p< 0,05 para la tendencia. Resultados: se seleccionaron 148 casos con neoplasias de células germinales. Existe tendencia del aumento en los tumores con p < 0.003. El 60.2% (89 casos; IC 95% 52.2-68.1), se presentó en menores de 30 años. Los tumores testiculares de células germinales no seminomatosos se presentaron en un 59.5% (88 casos), IC 95% (51.5-67.3); el promedio de edad para los no seminomatosos fue de 26.4 años, DE 8.1; y para los seminomatosos fue de 31 años, DE 7.5, con una diferencia calculada de p<0.001. Conclusiones: existe una tendencia significativa al aumento de los tumores testiculares de células germinales, que es más frecuente en menores de 30 años. Los tumores testiculares de células germinales no seminomatosos son los más frecuentes, cuyo promedio de edad es significativamente menor, que el de los TTCG seminomatosos. Se recomienda dirigir campañas de detección a población en riesgo y ampliar el estudio a otros hospitales.

tumores de células germinales; células germinales; seminoma, biopsia; Costa Rica.


Background: 95% of testicular tumors are germ cell tumors (TGCT). These neoplasms have increased in number and have become more common in young people. The TGCTs are divided into two groups: seminomatous and non-seminomatous. The objective is to describe the TGCT based on pathological biopsy results at the Mexico hospital from 1<span name="style_sup">st </span>january 2003 to 31<span name="style_sup">st </span>march 2011. Methods: A descriptive study of the department of Pathology database, from which the cases of TGCTs were selected. Within the analysis, absolute and relative frequencies, confidence intervals, measures of dispersion and central tendency were calculated. Chi-square p &lt;0.05 was used for the trend. Results: 148 patients with germ cell tumors were selected. There was an increasing tendency in tumors with p &lt;0.003. Out of the total number of cases, 60.2% (89), CI 95% (52.2-68.1), occurred in males younger than thirty years old. Non-seminomatous TGCTs occurred in 59.5% (88) of the cases, CI 95% (51.5-67.3). The average age of those with non-seminoma was 26.4 years; DE 8.1, and of those with seminoma was 31 years; DE 7.5, with a difference of p &lt;0.001. Conclusions: There is a significant tendency towards the increase of TGCT, which is more frequent in patients under 30. The non-seminomatous TGCTs are the most frequent. The average age for non-seminomatous TGCTs is significantly lower than for the seminomatous. Limitations: incidences and prevalences were not calculated. Recommendations: to focus detection campaigns on the population at risk, and extend the study to other hospitals.march 2011. Methods: A descriptive study of the department of Pathology database, from which the cases of TGCTs were selected. Within the analysis, absolute and relative frequencies, confidence intervals, measures of dispersion and central tendency were calculated. Chi-square p <0.05 was used for the trend. Results: 148 patients with germ cell tumors were selected. There was an increasing tendency in tumors with p <0.003. Out of the total number of cases, 60.2% (89), CI 95% (52.2-68.1), occurred in males younger than thirty years old. Non-seminomatous TGCTs occurred in 59.5% (88) of the cases, CI 95% (51.5-67.3). The average age of those with non-seminoma was 26.4 years; DE 8.1, and of those with seminoma was 31 years; DE 7.5, with a difference of p <0.001. Conclusions: There is a significant tendency towards the increase of TGCT, which is more frequent in patients under 30. The non-seminomatous TGCTs are the most frequent. The average age for non-seminomatous TGCTs is significantly lower than for the seminomatous. Limitations: incidences and prevalences were not calculated. Recommendations: to focus detection campaigns on the population at risk, and extend the study to other hospitals.

Germ cells; seminoma; biopsy; Costa Rica; testicular tumors


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Mexico Hospital, Costa Rica from January 2003 to march 2011

Julia Freer-Vargas, 1 Konstantin Liannoy, 2 Douglas Montero-Chacón 3

Epidemiology Department, Mexico Hospital.

1Epidemiology Department and2Pathology Department,Mexico Hospital,3General Director, MexicoHospital.

Abbreviations: SD, standard deviation;TGCT,testicular germ cell tumor.

Funding:This study used funds provided by the INCIENSA. jfreerhm@ccss.sa.cr

Mexico hospital from 1st January 2003 to 31st march 2011.

Conclusions: There is a significant tendency towards the increase of TGCT, which is more frequent in patients under 30. The non-seminomatous TGCTs are the most frequent. The average age for non-seminomatous TGCTs is significantly lower than for the seminomatous.
Limitations: incidences and prevalence were not calculated. Recommendations: to focus detection campaigns on the population at risk, and extend the study to other hospitals.

Costa Rica, testicular tumors

1-7

seminomatous and nonseminomatous (more aggressive tumors).2-8 The seminomatous are characterized by the presence of seminoma only, whereas, the nonseminomatous present embryonic carcinoma, yolk sac tumor, choriocarcinoma and/ or immature or mature teratoma. Furthermore, TGCT are characterized by combinations of two or more types of different tumors mentioned above.3

1-5 etc. It is well known that the higher incidence occurs in northern European countries such as Denmark, Germany, Norway, Hungary, Switzerland.

5 and they are diagnosed between 30 to 50 years old, with a mean age of 35.8, SD 8.6,5-6 while non seminomatous tumors present in 64.2% of cases,5 and these are most common in adolescence and early forties, with an average age of 29.1 years, and a SD of 8.9.6-5

MexicoHospital, a referral center that has specialties and subspecialties, located in the province of San José Costa Rica, canton of La Uruca.

MexicoHospital during the period January 1, 2003 to March 31, 2011.

MexicoHospital. The data were obtained from the database of the Pathology Department. The variables studied were number of biopsy, patient´s age at the time of the procedure, classification of the type of tumor: seminomatous and nonseminomatous (mixed embryonic carcinoma, yolk sac, immature teratoma, choriocarcinoma and mature teratoma).

Figure 1).

Figure 1

Table 1).

Table 1

Table 2).

Table 2

Figure 2).

Figure 2

Figure 3).

Figure 3

1,3,4

Costa Rica.

References

References

  •  1. American Cáncer Society. Cancerde testículo. Atlanta, Georgia: 23 marzo 2011.

  •  2. Richie J, Steele G. Neoplasias del Testículo. En: Patrick C. Walsh. Campbell Urología, 8 ed. Uruguay: Editorial Médica Panamericana: 2002. 3147-3154.

  •  3. La llave F, Lomas M, Laguna E, Asuar S, Murillo J, Ramírez A, et al. Estudio Descriptivo de los tumores testiculares germinales: 13 años de experiencia en el área de Salud Badajoz. Arch. Esp. Urol. 2007; 60: 531-537.

  •  4. Gorena M, Cinfuentes M, Gonzalez R, Villagran J, Hinostroza Ja, Pastor P, et al. Perfil clínico y epidemiológico del Cáncer Testicular en la Región. Rev Chil de Urol. 2003; 68: 78-82.

  •  5. Gutiérrez–Tejero F. Revisión Histogenéticosde los tumores testiculares Germinales (Tesis doctoral). Granada: Universidad 2007; 93-136 5.

  •  6. Ministerio de Salud de Chile. Guía Clínica Cáncer de testículo en personas de 15 años y más. Santiago Chile: MINSAL 2010.

  •  7. Saavedra J, Ramírez C Peña G, Stoopen M, Barois A, Kimura Y. Cáncer de testículo. An RadiolMex. 2009; 1:47-59.

  •  8. Gk Jacolsen, H Barbelo, J Olsen. Testicular germ cell tumors in Denmark 1976-1980. Acta Radiolog Oncol1984; 23: 239-247.

  •  9. SJ Harland. Intratubular germ cell neoplasia of the contralateral testis in testicular cancer: Defining a high risk group. J Urol1998; 160: 1353-1357.

en_bart06v55n1
Received: March 7, 2012 Accepted: September 21, 2012

References

  •  1. American Cáncer Society. Cancerde testículo. Atlanta, Georgia: 23 marzo 2011.

  •  2. Richie J, Steele G. Neoplasias del Testículo. En: Patrick C. Walsh. Campbell Urología, 8 ed. Uruguay: Editorial Médica Panamericana: 2002. 3147-3154.

  •  3. La llave F, Lomas M, Laguna E, Asuar S, Murillo J, Ramírez A, et al. Estudio Descriptivo de los tumores testiculares germinales: 13 años de experiencia en el área de Salud Badajoz. Arch. Esp. Urol. 2007; 60: 531-537.

  •  4. Gorena M, Cinfuentes M, Gonzalez R, Villagran J, Hinostroza Ja, Pastor P, et al. Perfil clínico y epidemiológico del Cáncer Testicular en la Región. Rev Chil de Urol. 2003; 68: 78-82.

  •  5. Gutiérrez–Tejero F. Revisión Histogenéticosde los tumores testiculares Germinales (Tesis doctoral). Granada: Universidad 2007; 93-136 5.

  •  6. Ministerio de Salud de Chile. Guía Clínica Cáncer de testículo en personas de 15 años y más. Santiago Chile: MINSAL 2010.

  •  7. Saavedra J, Ramírez C Peña G, Stoopen M, Barois A, Kimura Y. Cáncer de testículo. An RadiolMex. 2009; 1:47-59.

  •  8. Gk Jacolsen, H Barbelo, J Olsen. Testicular germ cell tumors in Denmark 1976-1980. Acta Radiolog Oncol1984; 23: 239-247.

  •  9. SJ Harland. Intratubular germ cell neoplasia of the contralateral testis in testicular cancer: Defining a high risk group. J Urol1998; 160: 1353-1357.

en_bart06v55n1
Received: March 7, 2012 Accepted: September 21, 2012

Publication Dates

  • Publication in this collection
    01 Aug 2013
  • Date of issue
    Mar 2013

History

  • Received
    07 Mar 2012
  • Accepted
    21 Sept 2012
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