During recent years there has been a remarkable increase in the production of foods sweetened sugar substitutes with less caloric value, that are used in dietary programs to lose weight to maintain a healthy weight as well as to offer options for individuals with diabetes or glucose intolerance. One of the most common sweeteners is high fructose corn syrup, a less expensive sweetener that has a lower postprandial hyperglycemic effect compared to sucrose. However new research has shown that prolonged consumption of high fructose diet would contribute to the development of chronic diseases such as obesity, diabetes, lipid disorders, metabolic syndrome and cardiovascular diseases. This paper describes the possible metabolic implications related to different diseases associated with an excessive fructose consumption.

fructose; corn syrup; high infructose; obesity; insulin resistance; dyslipidemia